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Gabriel Birkuš Selected Research

Proteins (Proteins, Gene)

1/2024Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction.
11/2023Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
1/2022Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
12/2021Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
1/2021Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
1/2021Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
12/2019Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.

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Gabriel Birkuš Research Topics

Disease

10Bites and Stings (Sting)
02/2024 - 12/2019
6Neoplasms (Cancer)
02/2024 - 01/2011
1Breast Neoplasms (Breast Cancer)
11/2023
1Infections
11/2023
1Human Influenza (Influenza)
06/2021
1Bacterial Infections (Bacterial Infection)
12/2019

Drug/Important Bio-Agent (IBA)

9InterferonsIBA
01/2024 - 12/2019
7Proteins (Proteins, Gene)FDA Link
01/2024 - 12/2019
5ProdrugsIBA
11/2023 - 01/2011
4LigandsIBA
11/2023 - 01/2021
4CytokinesIBA
12/2021 - 12/2019
3DNA (Deoxyribonucleic Acid)IBA
02/2024 - 01/2022
3cyclic guanosine monophosphate-adenosine monophosphateIBA
02/2024 - 12/2019
2Interferon Type IIBA
10/2021 - 01/2021
1Antiviral Agents (Antivirals)IBA
02/2024
17-deazapurineIBA
10/2022
1ADU-S100IBA
01/2022
1Vidarabine PhosphateIBA
12/2021
1FluorineIBA
10/2021
1NucleosidesIBA
06/2021
1phosphoramidic acidIBA
06/2021
1Phosphotransferases (Kinase)IBA
12/2019
1Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA
12/2019
1Cytostatic AgentsIBA
01/2011

Therapy/Procedure

2Immunotherapy
11/2023 - 10/2022
1Immunomodulation
11/2023